![]() Physical stiffening of the large arteries is recognized as the consequence of chronic irreversible vascular aging and deposition of atherosclerotic plaques along the arterial walls. Stiffer arteries are susceptible to rise in ΔP level due to the reduction in arterial compliance and associated increase wave reflection amplitude and PWV. The numeric difference between SBP and DBP, referred to as pulse pressure (ΔP), is dependent on the cardiac output, elastic behavior of the aorta and large arteries, blood pulse wave reflection and pulse wave velocity (PWV). Among the parameters that characterize BP, the systolic BP (SBP) and diastolic BP (DBP) values are widely used as an independent predictor of future cardiovascular risks and outcomes. ![]() The prognostic importance of arterial blood pressure (BP) parameters as a risk factor for cardiovascular events is well established. There was no additional external funding received for this study.Ĭompeting interests: The authors have declared that no competing interests exist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Mohanasankar Sivaprakasam, Healthcare Technology Innovation Centre, Indian Institute of Technology Madras, India. The authors confirm that all data underlying the findings are fully available without restriction.įunding: This work was supported by Science and Engineering Research Board (SERB), Department of Science and Technology, Government of India under grant IUSSTF/NIBIB_DST/ABPM/2013-2014/EOI_12 for Indo-US Grand Challenge Initiative – ‘Affordable blood pressure measurement technologies for low resource settings’ for the project ‘Arterial compliance probe for cuff-less blood pressure measurement’ under the guidance of Dr. Our individual level participant data including measurements obtained from the developed prototype device is available in the supporting information. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are in the paper. Received: ApAccepted: AugPublished: August 16, 2018Ĭopyright: © 2018 Joseph et al. ![]() ![]() PLoS ONE 13(8):Įditor: Yoshihiro Fukumoto, Kurume University School of Medicine, JAPAN Like the reference brachial blood pressure (BP) monitor, the developed prototype device reliably captured variations in carotid local ΔP induced by an external intervention.Ĭitation: Joseph J, P M N, Shah MI, Sivaprakasam M (2018) Arterial compliance probe for cuffless evaluation of carotid pulse pressure. ![]() Consistent with the physiological phenomenon, local ΔP measured from the carotid artery of young populations was, on an average, 22 mmHg lower than the reference ΔP obtained from the brachial artery. The group average beat-to-beat variation in measured carotid local PWV, arterial diameter parameters-distension and end-diastolic diameter, and local ΔP were 4.2%, 2.6%, 3.3%, and 10.2% respectively in physically relaxed condition. The ability of the developed system to acquire high-fidelity waveforms (dual MPG signals and ultrasound echoes from proximal and distal arterial walls) from the carotid artery was demonstrated by the in-vivo validation study. Phantom-based verification study yielded a correlation coefficient (r) of 0.93 (p < 0.001) for estimated ΔP versus reference brachial ΔP, with a non-significant bias and standard deviation of error equal to 1.11 mmHg and ☑.97 mmHg respectively. ![]()
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